San Marino in the Quackvision Song Contest 01

Background
Main Article: San Marino

San Marino was announced to be one of the countries that were confirmed to participate in the inaugural edition of the Quackvision Song Contest, with DubbleTrubbleBoy as their head of delegation for the edition. As with all the other countries competing in this edition, it was their official debut in the contest.

Internal Selection
Alessia Labate was announced to be the representative for San Marino for the first edition of the Quackvision Song Contest, being the thirteenth song to be revealed for the contest. The song was revealed to be "Highway", a song sung entirely in English.

Grand Final
Nearing the end of the Song Reveal period for the edition, the Quackvision Event 01 revealed the halves that the contestants would be performing in, with the final running order being revealed on 31 July 2021. For the show, San Marino was placed in the first half, performing eight, following the entry from South Korea and preceding the entry from Ireland. At the end of the show, San Marino placed fifteenth in the final, scoring 57 points: 35 from the televote (14th) and 22 from the juries (17th).