U.S. Virgin Islands in the Quackvision Song Contest 01

Background
Main Article: U.S. Virgin Islands

The U.S. Virgin Islands were announced to be one of the countries that were confirmed to participate in the inaugural edition of the Quackvision Song Contest, with nonowastakeer as their head of delegation for the edition. As with all the other countries competing in this edition, it was their official debut in the contest.

Internal Selection
Madison Rose was announced to be the representative for the U.S. Virgin Islands for the first edition of the Quackvision Song Contest, being the third song to be revealed for the contest. The song was revealed to be "Lost My Mind (To The DJ)", a song sung entirely in English.

Grand Final
Nearing the end of the Song Reveal period for the edition, the Quackvision Event 01 revealed the halves that the contestants would be performing in, with the final running order being revealed on 31 July 2021. For the show, the U.S. Virgin Islands were placed in the second half, performing tenth, following the entry from Ireland and preceding the entry from Belgium. At the end of the show, the U.S. Virgin Islands placed third in the final, scoring 203 points: 106 from the televote (2nd) and 97 from the juries (2nd).